The phosphodiesterase gene has evolved in certain populations and is involved in numerous functions, increasing the likelihood of mutations affecting multiple systems.

“Uh and I mean you know to your point like the phosphodiestase that we found that was evolving in the Bajjo phosphodiestases are involved in so many different functions and so there's you know there are chances for these mutations to affect not just the systems that we're interested in but other systems as well.”