The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
this is crucial since acidification is crucial for endosome maturation and function we surmise that endosome maturation might be blocked at intermediate stages of endocytosis resulting in failure of further transport of variants variants to the ultimate releasing site
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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showing here abnormally enlarged endo lysosomes and an endosome x' so early endosomes and end of lysosomes were enlarged with chloroquine and hydroxychloroquine
their conclusion was this may negatively influenced by receptor binding and abrogate the infection I love that word abrogate with further ramifications by the elevation of a circular pH resulting in the inhibition and infection and spread of Tsarskoe v at clinical admissible concentrations
lysosomes and endo lysosomes these cellular vesicles in which the virus is essentially assembled and exported out of the cell and if you raise the pH of those in the somes it appears that perhaps the virus is unable to do its work of reassembly and is less effective in our cells so that may be one of the mechanisms by which chloroquine is working
there may also be some other mechanisms at play as well as chloroquine has been shown to impair early stage application of the virus by interfering with pH dependent endosome mediated viral entry into the cell