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Rapamycin extends mouse lifespan 9–14%
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CHLOROQUINE for SARS CoV2? — Whalespan

Content›Video›CHLOROQUINE for SARS CoV2?…

CHLOROQUINE for SARS CoV2?

Paul Saladino17m · 2020-03-20

Claims Made

33

Claims Supported

22

Support Rate

67%

Support rate

22 of 33 claims supported

22 supported11 partial / not

Claims from this content

23

✓Well SupportedChloroquine and hydroxychloroquine treatment resulted in abnormally enlarged endo-lysosomes and endosomes, potentially blocking viral transport.✓Well SupportedHydroxychloroquine and chloroquine demonstrated similar efficacy in inhibiting SARS-CoV-2 replication in vitro.◐Partially SupportedChloroquine may interfere with the terminal glycosylation of the ACE2 receptor, potentially inhibiting coronavirus binding and entry into cells.◐Partially SupportedChloroquine was shown in a 2005 study to be a potent inhibitor of SARS-CoV-1 in cell culture.Partially Supported

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◐

The lethal dose for chloroquine and hydroxychloroquine in adults is approximately four grams.

✕Not SupportedChloroquine side effects include blurred vision, itching, neurological paresthesia, insomnia, and skin stinging.

✕Not SupportedChloroquine and hydroxychloroquine carry a risk of fetal damage during pregnancy and are extremely dangerous in acute overdose.

✕Not SupportedA daily dose of one gram of chloroquine (500mg twice a day) can be toxic.

✕Not SupportedChloroquine should not be taken prophylactically due to its numerous side effects.

✕Not SupportedRetinopathy is a common side effect of chloroquine and hydroxychloroquine.

◐Partially SupportedChloroquine may be a great intervention for individuals severely affected by illness, despite its many side effects.

◐Partially SupportedChloroquine treatment in malaria reduced symptoms like headache and fever but increased gastrointestinal symptoms.

◐Partially SupportedChloroquine and hydroxychloroquine have been used traditionally for malaria and other infections.

✕Not SupportedChloroquine and hydroxychloroquine have side effects including skin problems, hyperpigmentation, photodynamic reactions, hair changes, corneal deposits, accommodation disturbances, neuro myopathy, central nervous system disturbances, impaired auditory function, and blood cell formation issues.

◐Partially SupportedThe coronavirus poses a greater risk to the elderly and individuals with pre-existing health conditions.

◐Partially SupportedA 103-year-old individual recovered completely from coronavirus.

◐Partially SupportedHydroxychloroquine is approximately 40% less toxic than chloroquine in animals.

◐Partially SupportedChloroquine may work by elevating endosomal pH, which could interfere with the virus's reassembly and effectiveness within cells.

◐Partially SupportedChloroquine and hydroxychloroquine can be used at a certain maximum dosage based on body weight to avoid retinopathy.

◐Partially SupportedHydroxychloroquine may be efficient at inhibiting SARS-CoV-2 in cell culture.

◐Partially SupportedPost-infection treatment with chloroquine reduced SARS-CoV infection and spread.

◐Partially SupportedChloroquine and hydroxychloroquine may be used to treat severe cases of infection.

◐Partially SupportedExpert consensus recommends 500mg of chloroquine phosphate twice daily for 10 days to treat novel coronavirus pneumonia without contraindications.