David Sinclair· PhD
But also, what glucose is going to be doing to you at high levels, is shutting off those protective mechanisms. Remember, particularly AMPK and the sirtuins. They get switched off by sugar.
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
But also, what glucose is going to be doing to you at high levels, is shutting off those protective mechanisms. Remember, particularly AMPK and the sirtuins. They get switched off by sugar.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.