The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
There's people that have SNPs in heat shock protein factor 70 that, if they have one of them, so they got one from their parents where they have more active heat shock protein 70, they live on average one year longer than people that don't have that SNP. And if they have two versions, if they got one from their mom and one from their dad, they live on average two years longer than people that don't have that SNP.
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Individuals with one copy of this variant tend to live about a year longer, while those with two copies can expect to live an additional two years compared to those without this genetic advantage.
Specific genetic variations in the HSP70 gene, which enhances its activity, have been linked to longer lifespans.
heat chock proteins have also been associated with human longevity so humans that have a variation in a gene that makes hog proteins uh live have exceptional longevity
and people that have one copy so they're heterozygous for that snip live about one year longer
Humans that have two copies of that so they're homozygous have a two are basically on average live two years longer than people that don't have that snip
Individuals have variations in the heat shock 70 gene that make them have a more active heat shock 70 gene. So they're making more heat shock protein 70, which is one of the major heat shock proteins. If those individuals have one copy from either mom or dad, that's associated with a one-year increase in life expectancy compared to people that don't have any of those copies.