David Sinclair· PhD
Chronic inflammation speeds up every hallmark of aging.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Chronic inflammation speeds up every hallmark of aging.
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and then every time we create a new biologic aging clock, which we're doing a lot of now in my lab, you know, and we do principal components and figure out what the main driver is, it it's always related to inflammation.
Every time we do an experiment, we keep coming back to inflammation. All of the interventions that extend lifespan, reduce chronic inflammation or almost all of them. And then every time we create a new biologic aging clock, which we're doing a lot of now in my lab, you know, and we do principal components and figure out what the main driver is, it it's always related to inflammation.
all of the interventions that extend lifespan, reduce chronic inflammation.
uh and so I I think there's something it may not be inflammation may be a response but it's so central that uh a lot of the interventions I think are working by dampening inflammation
All of the interventions that extend lifespan, reduce chronic inflammation or almost all of them.
All of the interventions that extend lifespan, reduce chronic inflammation or almost all of them. And then every time we create a new biologic aging clock, which we're doing a lot of now in my lab, you know, and we do principal components and figure out what the main driver is, it it's always related to inflammation.
and then every time we create a new biologic aging clock, which we're doing a lot of now in my lab, you know, and we do principal components and figure out what the main driver is, it it's always related to inflammation.
We would argue for two hours in some conference room somewhere in the world and at the end of it we would come up with the definition happens and then you die. You know it's you know every time we do an experiment we keep coming back to inflammation. All of the interventions that extend lifespan reduce chronic inflammation.
Chronic inflammation is tightly linked to biological aging.
Well, yeah, inflammation is a driver of aging. So you're talking about these diseases which many are age-related. So you're...it's a really...like you said it's at the heart of all these diseases. When I think that really is a driver of the aging process itself.
He he says that these these epigenetic agent clocks are very sensitive to inflammation. In fact it's one of the things that really accelerates the aging process inflammation.