Peter Attia· MD
drugs that only extend the median and don't affect the age of death of the longest live 5 or 10 percent they might be interesting in some ways but they are considered less plausible as candidates for anti-aging drugs
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
drugs that only extend the median and don't affect the age of death of the longest live 5 or 10 percent they might be interesting in some ways but they are considered less plausible as candidates for anti-aging drugs
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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in terms of biology and pathobiology and being able to compare lab a to lab b drug a to drug b i think keeping it on the level of what is the change in the overall median is important
if you have a drug that's authentically slowing aging one of the things you most want to see is that the very oldest animals in this drug-treated group are living longer than the very oldest animals in the untreated control group