Some women experience significant premenstrual syndrome symptoms due to a reduction in progesterone after ovulation and sensitivity in central progesterone receptors.

“So we talked about how of course during the ludial phase we're building up you know progesterone levels are rising we're building up the endometrial lining in preparation for uh pregnancy again most of the times that's not going to happen lining sheds progesterone crashes this is what's referred to as you know obviously PMS and some women are somewhat unfased by that you know and other women that's a big deal and so the question is is this about central receptors of progesterone and varying degrees of”