Reproducible results across multiple labs in mouse models provide strong evidence for a biological signal.

“we have just an overabundance of mouse data that are so reproducible and reproducible in really good Mouse models um you know as you know I'm sure from your work um the model you choose matters right and and sort of you you you know in an Ideal World you want to use a mouse model that is um you know not inbred that is more closely related to the what we care about which is ourselves and and so when you see many Labs getting the same result over and over again regardless of how they do it you you really start to believe there's a signal there”