Aging is an organized systems phenomenon characterized by a coordinated transcriptional state associated with mortality risk.

“The work is also the strongest systems-level support yet for the idea that aging is not just random wear and tear, but a coordinated and reversible loss of biological information. In many ways, it strengthens the Information Theory of Aging (ITOA), which we first formulated back in 2008-2009. The striking thing is not simply that damage accumulates. It is that cells enter a coordinated transcriptional state associated with mortality risk, which strongly argues aging is an organized systems phenomenon.”