Combining screening tests with different sensitivities and specificities can significantly improve cancer detection.

“adding ultrasound or MRI to the breast surveillance program won't dramatically by stacking tests with different sensitivities and specificities right mammography exceptional for small calcified lesions Works poorly in hyper glandular tissue right the exact opposite is true with the MRI similarly with the PSA by itself virtually meaningless but PSA density PSA velocity now adds much more specificity furthermore you start to add things like a 4K and if the risk is high enough you get you know multi-parametric MRI”