Melatonin receptor and clock genes are significant factors influencing obesity and diabetes.

“almost 10 years ago large genome-wide association studies found that people with obesity or diabetes might have a mutation in melatonin receptor.”

“this study this kind of studies came to publication because almost 10 years ago large genome-wide Association studies found that people with obesity or diabetes might have a mutation in melatonin receptor and that was confusing because what is monitoring to do with obesity and diabetes”

“And to make it even more complicated, going back to the discovery of that melatonin receptor variant, nearly one-third of the population had that variant. So that means they're more likely to be influenced by this relatively, benignly moderately high level of melatonin being in their system and not being able to control their blood glucose.”

“in 2009, simultaneously four different papers came out from human genetic studies showing that people with diabetes or increased fasting blood glucose level have a polymorphism or mutation in the melatonin receptor gene.”