The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
The only population where we typically see some benefit, and it often is prescribed is in older adults, because as we. - Older meaning 60 and older? - Yeah, 60, 65 and older because as we get older, you can typically have what's called calcification of the pineal gland. Which means that that gland that's releasing melatonin doesn't work as well anymore. As a consequence, they tend to have a flatter overall curve of melatonin release throughout the night.
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as we get older you can typically have what's called calcification of the pineal gland which means that that gland that's releasing melatonin doesn't work as well anymore. That's why older adults can have problems falling asleep or staying asleep. It's not the only reason by any stretch of the imagination, but it's one of the reasons and it's why melatonin supplementation in those cohorts, older adults, especially older adults with insomnia, people have thought about that as maybe an appropriate use case.
And that's at least from the studies that I've seen in like around 40 years, your pineal gland starts to make less and less melatonin.