We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
One of the things that I'm concerned about about these super physiological levels of melatonin is that many years ago, actually, here at Berkeley, when I was a graduate student, we would inject animals which were seasonally breeding animals with melatonin. And the consequence of that was that their gonads, either their testes or ovaries would shrink, many hundred fold or more.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
melatonin I'm not a fan of melatonin at all doses on the shelves in stores are massively super physiologic and I think this could have major consequences for humans there's good evidence that in animal models giving megadoses of melatonin shrinks the gonads so you tell me how much Melatonin you want to take guys I don't want to take it
models giving megadoses of melatonin shrinks the gonads so you tell me how much Melatonin you want to take guys I don't want to take it
melatonin I'm not a fan of melatonin at all doses on the shelves in stores are massively super physiologic and I think this could have major consequences for humans there's good evidence that in animal models giving Mega doses of melatonin shrinks the gonads