Endogenous melatonin positively impacts bone mass by stimulating osteoblast production and has antioxidant and potential anti-cancer effects.

“Endogenous melatonin, meaning the melatonin that we make within our bodies naturally, not melatonin that's supplemented, has two general categories of effects. The first set of effects are so called regulatory effects and the others are protective effects. The regulatory effects are for instance, that melatonin can positively impact bone mass. So melatonin can, for instance, turn on the production of osteoblasts, which are essentially stem cells that make more bone for us that make our bones stronger and that can replace damaged aspects of our bone. [...] As I mentioned before, melatonin also has protective effects. It can activate our immune system. It is among the most potent antioxidants. So it is known to have certain anti-cancer properties and things of that sort”