Melatonin, secreted as sleep approaches, may transiently impair insulin sensitivity, potentially leading to less effective glucose absorption later at night.

“the antagonistic relationship between melatonin and insulin is quite interesting and the fact that people got insulin resistant when they got melatonin in the morning and then I think the reverse like if we're eating late at night it could throw it off and you might not get as much melatonin”

“Our insulin works on a circadian rhythm just like our other hormones, just like melatonin. And so we have less insulin sensitivity in the evening and we're not secretreting as much insulin.”

“so i use this as an argument perhaps a shallow argument but nevertheless an argument that i use for myself to eat my meals early in the day i don't want to have a bunch of insulin at night to prevent the secretion of melatonin”

“interestingly there is evidence that insulin and melatonin are contradictory hormones that melatonin may inhibit the secretion of insulin or vice versa”

“if we want to eat more during sunlight hours then we may need to eating our dinner at different times in the summer versus the winter because we know that like once that melatonin starts getting secretion it does impact our insulin sensitivity”

“In the evening, especially in the hours before bed, our bodies are at their least insulin-sensitive. As melatonin levels rise, it interacts with receptors in the pancreas, signaling a reduction in insulin secretion.”

“So that's one case where we might think that late night, even if you control food calorie, the same calorie taken in late in the night versus early in the evening might have different effect.”

“So that's why people who are eating late into the night, they may not get the best benefit in terms of glucose control because their glucose might remain slightly higher than if they had the same dinner two hours earlier.”