Tolerance in addiction can be overcome by increasing dose, frequency, changing delivery mechanism, or altering chemical combination.

“tolerance is the phenomenon of finding that the drug stops working over time um and that we need more and more to get the same effect or more more potent forms and and and tolerance is overcome by using more using more often or overcoming tolerance by changing the delivery mechanism instead of you know orally ingesting maybe smoking or injecting or um overcoming tolerance by changing slightly the chemical combination or moyy or combining drugs together so that the brain sees something that's similar but slightly novel”