MDMA changes resting state functional connectivity within limbic structures associated with threat detection.

“the fact that the degree of reduction of connection of this circuit scales with the reduction in clinically relevant symptoms that's a very powerful finding because it moves things away from Pure correlation although this brain area is active or less active over time and you know this person has more or fewer symptoms of PTSD to something that starts to look like a mechanistic and logical framework for understanding PTSD as well as the effects of MDMA and for understanding how changes in the brain underlie relief from PTSD”