Andrew Huberman· PhD
Many of you have probably heard of endorphins. Endorphins are a category of molecules that are made naturally in your brain and body and that are released in response to different forms of stressors.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Many of you have probably heard of endorphins. Endorphins are a category of molecules that are made naturally in your brain and body and that are released in response to different forms of stressors.
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The first are the ones that you normally hear about, endorphins, things that bind for instance to receptors like the mu opioid receptor. Opioids are not just prescribed compounds or unfortunately drugs of abuse, which they are. We have this opioid crisis in the United States and elsewhere, which is a very serious and tragic thing, but we make endogenous opioids. We make endorphins that naturally act as pain relievers and that make us feel mildly euphoric.
We also make endorphins such as dynorphine, that's D-Y-N-O-R-P-H-I-N-E, dynorphine, that actually make us feel worse in response to stressors.
Endorphins are a category of molecules that are made naturally in your brain and body and that are released in response to different forms of stressors.