The glutamate hypothesis of schizophrenia involves an imbalance between excitatory and inhibitory systems in the cortex, involving NMDA receptors.

“so this is interesting so this is this is telling us I think that we should be thinking about uh and now there's a whole field now in Psychiatry that has to do with uh you know the glutamate hypothesis for the the the first uh where where the actual um imbalance first occurs it's an imbalance between the exciting inhibitory systems that are in the cortex are keep you in balance and nmda and methylaspartate receptors are glutamate receptors one one class that's one class that's right”