Andrew Huberman· PhD
Dynorphine binds to what's called the CAPA receptor. The CAPA receptor binds dynorphine and triggers pathways in the brain and body that lead to agitation, to stress, and believe it or not to a general sense of pain.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Dynorphine binds to what's called the CAPA receptor. The CAPA receptor binds dynorphine and triggers pathways in the brain and body that lead to agitation, to stress, and believe it or not to a general sense of pain.
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