Paul Saladino· MD
when you start looking through at it from this mechanistic perspective you start seeing the exact same processes going on you see cardiolipin oxidation leading to mitochondrial dysfunction leading to inability of cells to oxidize substrates leading to production of these toxins like hne which creates a signal that causes macrophages to attack these cells which leads to inflammation from the macrophages producing cytokines which causes more macrophages to come in which causes cellular dysfunction like you've talked about with adipocytes not being able to divide the way they should and what you pretty quickly realize is that the mechanisms in all of these different disease states are common there's one process that's going on and it's a cellular process right it's not a organ specific process it's the fact that all of these cells contain mitochondria and the mitochondria are breaking down in a common way