Increased insulin binding to fat cells, driven by high PUFA diets, leads to growing fat cells and can result in metabolic dysfunction.

“except you don't want insulin to bind to your fat cells because insulin sensitive fat cells are fat cells that are growing so what this is pretty clearly showing is that when you feed animals which have the same physiology the level of their fat cells in terms of insulin high diets high in polyunsaturated fat highly unsaturated fat to saturated fat what you get is insulin binding that is increased and fat cells that are growing”