Skeletal muscle inactivity leads to metabolic derangement, including fatty acid infiltration, decreased flux, reduced glycogen utilization, buildup of ceramides and diacylglycerols, and potential insulin resistance.

“the skeletal muscle inactivity causes a derangement of metabolism the derangement of metabolism will then go on to get fatty acid infiltration fatty acids that infiltrate into skeletal muscle once that happens you now have a decreased flux you're not moving muscle glycogen you're not getting rid of these ceramides or these diog glycerols that build up that potentially lead to an compound insulin resistance skeletal muscle insulin resistance”