Paul Saladino· MD
there's so much good evidence that polyunsaturated fat is horrible for humans that it's making our fat cells grow which leads to badness that is eventually what leads to metabolic dysfunction
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
there's so much good evidence that polyunsaturated fat is horrible for humans that it's making our fat cells grow which leads to badness that is eventually what leads to metabolic dysfunction
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Polyunsaturated fats create an inappropriate persistent signal that the cells can accept more nutrients which is a bad thing stuffing your body full of linoleic acid grows your adipocytes they become hypertrophic
so gradually polyunsaturated fats push you along the road to metabolic dysfunction now i'm not saying all polyunsaturated fats are bad in all quantity they're not a toxic thing but the amount matters excess evolutionarily inconsistent consumption of massive amounts of polyunsaturated fats specifically linoleic acid is a signal to your adipocytes to grow to become hypertrophic to limit adipogenesis to limit hyperplasia to become big and fat and sick the button bursts on the pants you get free fatty acids leaks and that is when metabolic dysfunction aka metabolic syndrome aka diabetes really starts and that is a problem that is what you do not want you guys that is at the root of chronic disease