Controversial Thoughts: PUFA in Keto, PUFA in Cancer!

PS

Paul Saladino20m · 2020-09-30

Claims Made

31

Claims Supported

19

Support Rate

61%

Support rate

19 of 31 claims supported

19 supported12 partial / not

Claims from this content

27

Well SupportedIndigenous populations studied typically consume diets where linoleic acid constitutes about 2% of fat intake, contrasting with 7-15% in Western diets.Well SupportedConsuming desiccated organs can provide unique nutrients that are difficult for humans to obtain otherwise.Well SupportedA diet of nose-to-tail animal foods, seasonal fruit, honey, and occasional tubers supports metabolic health.Well SupportedMetabolic health and dysfunction are major determinants of an individual's response to SARS-CoV-2 infection.Partially Supported

Discussion

Native comments, Twitter mentions, and Reddit threads about this content — surfaced together so the conversation isn't fragmented across platforms.

M

Share your read of this content…

Posting publicly as you · linked to your social profiles

Sort by:

AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Focusing on metabolic health is more important than hiding from coronavirus.

Partially SupportedMetabolic health is important for the immune system's ability to fight viruses.

Not SupportedPolyunsaturated fat (PUFA) is detrimental to humans, causing fat cells to grow and leading to metabolic dysfunction.

Partially SupportedMitochondrial breakdown of saturated fats can lead to reverse electron transport, ROS production, and insulin resistance signaling.

Partially SupportedMeat is not the cause of health problems and should not be feared, as animal foods contain unique nutrients not found in plants.

Partially SupportedWhen cells are insulin-sensitive in the presence of polyunsaturated fats, CD36 translocates to the plasma membrane, facilitating free fatty acid uptake and fat accumulation.

Partially SupportedConsuming 3-4% linoleic acid in the diet is not excessive, while current average intake levels (6-14%) may obscure epidemiological signals linking linoleic acid to cancer.

Not SupportedMost individuals do not want to be in a constant state of ketosis, as muscle insulin sensitivity and glucose disposal are desirable for metabolic health.

Not SupportedMany studies linking higher serum linoleic acid to negative outcomes are small and use inaccurate measurements.

Partially SupportedDiets with higher percentages of linoleic acid are associated with a significant increase in mammary tumors in rats.

Partially SupportedModern humans experience more chronic disease, less vitality, and reduced activity ability despite similar lifespans to 100 years ago.

Not SupportedExcess linoleic acid may enable SARS-CoV-2 signaling and be necessary for SARS-CoV-2 replication.

Not SupportedPolyunsaturated fats (PUFAs) in ketogenic diets can lead to inappropriate insulin sensitivity at the mitochondrial level, causing adipocyte hypertrophy.

Partially SupportedDietary levels of essential fatty acids influence the incidence of mammary tumors in rats.

Partially SupportedHeart and Soil supplements are of high quality and are developed with a US-based supply chain.

Partially SupportedSaturated fats and polyunsaturated fats have distinct effects on mitochondria, influencing the FADH2/NADH ratio, ROS production, and insulin signaling.

Not SupportedExcess polyunsaturated fats are a primary driver of metabolic dysfunction, metabolic syndrome, and diabetes.

Partially SupportedRecent CDC estimates show SARS-CoV-2 case fatality rates below 0.1%, which is lower than the flu.

Partially SupportedLinoleic acid supplementation may synergize with rendezvous drug to suppress SARS-CoV-2 replication in vitro.

Partially SupportedLinoleic acid binding to the SARS-CoV-2 spike protein stabilizes its locked S conformation.

Partially SupportedLinoleic acid sequestration by SARS-CoV-2 could be a mechanism driving immune dysregulation and inflammation in coronavirus infection.

Partially SupportedHigh linoleic acid levels in red blood cells or serum should be correlated with SARS-CoV-2 outcomes to assess its impact.

Partially SupportedAnimal models involving polyunsaturated fats are highly translatable to humans due to shared mechanisms at the mitochondrial electron transport chain and NADH levels.