Transient increases in LPS may not be fully counteracted by the anti-inflammatory effects of an insulin spike, potentially leading to a discordant lipoprotein profile with more small, dense LDL to which LPS can bind.

“you also have a scenario where things like transient increases in lps like postprandial endotoxemia you don't have the beneficial anti-inflammatory effects of an insulin spike to counteract that and then you're also going to have things like um a discordant lipoprotein profile where you can have more small dents ldl where lps is going to bind to and not be cleared”