The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
you've talked about the trifecta or the the big three mitochondria inflammation and oxidative stress as three critical factors underlying metabolic dysfunction and I'm presuming those are also the Avenues to address in order to create metabolic function
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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there's about nine things okay and this is what I was led to so it's our diet okay it's our lack of sleep it's our incredibly sedentary Behavior it's chronic stress so psychological stress and poor emotional health it is environmental toxins it is our modern relationship with light so circadian see or circadian disruption based on our new relationship with sunlight and artificial light it's issues with how we relate to temperature um so the fact that we live a Thermon neutral existence now we're all at 72 degrees and we don't have thermal stimuli to promote metabolic health and certainly microbiome issues which is kind of tied to food but also separate from food because there's a lot of other things destroying our microbiome and lastly it's the medications we're taking it's the it's the total and utter overuse of over-the-counter and prescription medications many of which directly cause mitochondrial dysfunction oxidative stress
what's causing that is is usually some Confluence of what I mentioned before the mitochondria that actually make the energy being damaged this machine that makes the power makes the gas has a problem functioning that can be to a lot of different things that underpowering and distress leads the immune system to get revved up because what could be more inflammatory to a body than cells that can't do their work they're sending out distress signals and then the immune system tries to help but the immune system can't help because it's the problem is caused by the environment they can't take the doughnut out of your hand and so you get this stew of chronic inflammation trying to help these distressed underpowered cells but they're impotent in the face of the threats and then you have this other thing oxy of stress that's basically the damage mitochondria that can't do their work properly send out exhaust and sort of you know create damaging byproducts um that that cause essentially like a a chain reaction of Destruction in the cells that leads to a lot of problems