David Sinclair· PhD
ostensibly due to chromatin remodeling
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
ostensibly due to chromatin remodeling
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Exogenous ketones may combat metabolic syndrome. In rats with metabolic syndrome, supplementation with the BHB precursor 1,3-butanediol (a ketone supplement I take), flipped an epigenetic switch, increasing chromatin accessibility and upregulating fat breakdown genes in the kidney, liver, heart, and skeletal muscle.
supplementation with the BHB precursor 1,3-butanediol (a ketone supplement I take), flipped an epigenetic switch, increasing chromatin accessibility and upregulating fat breakdown genes in the kidney, liver, heart, and skeletal muscle.
This reduced body weight, blood pressure, and blood glucose without harming the liver.