Andrew Huberman· PhD
the visceral fat does not drain into the into the systemic circulation it drains into the portal vein which goes straight to the liver so you're getting a bigger load going straight to the liver of cyto kindes not to the kidney
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the visceral fat does not drain into the into the systemic circulation it drains into the portal vein which goes straight to the liver so you're getting a bigger load going straight to the liver of cyto kindes not to the kidney
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this visceral fat is particularly harmful for humans and it indicates metabolic dysfunction it's been associated with inflammation and insulin resistance as well
it's when that spills out into the viscera into the liver into the peripancreatic space into the perinephric space into the pericardial space it's that fat that escapes the normal depot of sub-q fat that is truly inflammatory and truly metabolically disturbing
it becomes problematic when it escapes those areas and gets around the viscera gets around our organs enters the muscle Itself by the way that's how it directly contributes to insulin resistance uh when it accumulates in the liver accumulates around the heart within the pancreas itself where it serves the double role of not just creating an inflammatory environment but also reducing the amount of insulin that the beta cell can release um and also around the the kidneys