Individuals with Dunnigan lipodystrophy have insulin resistance and aggressive atherosclerosis, despite not having elevated LDL.

“there's on the flip side there's familial dunnigan hyperlipidystrophy where people have normal levels of ldl but they have accelerated atherosclerosis and in the case of familial dunning and hyperlipidostrophy hyperlipid dystrophy like that one is fascinating because there's a mutation that causes them to be insulin resistant so they distribute their fat”