Paul Saladino· MD
So, anyone that sells the CALERIE trial as showing that caloric restriction has benefits in healthy individuals hasn't read the paper carefully enough.
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
So, anyone that sells the CALERIE trial as showing that caloric restriction has benefits in healthy individuals hasn't read the paper carefully enough.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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here's the hot take caloric restriction only leads to improvements in metabolic function in humans when those humans are obese we see that in the calorie trial those humans were obese with a BMI up to 27.3 though the authors didn't really say that though the authors don't make note of that so there are no good trials in humans showing that an otherwise healthy human benefits from calorie restriction