Andrew Huberman· PhD
when you go to the twin group it's 24.73 to 12.94
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when you go to the twin group it's 24.73 to 12.94
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if you do that all of a sudden the uh Hazard ratio drops from 1.48 to 1.32 which means yep you still have a 32 percent greater chance of dying in any given year all right what if we also adjust for the highest level of Education along with any of the other covariates well that doesn't really change it at all it ends up at 1.33 or a 33 chance increase in depth
the unadjusted model is brutal 2.15 that's a hundred and fifteen percent think about this these are twins who in theory are the same in every way except one has diabetes and one doesn't and the one with diabetes on Metformin still has 115 percent greater chance of dying than the non-diabetic co-twin when you make that first adjustment of all the meds and marital status you bring it down to a 70 increase in risk and when you throw education in it goes up to an 80 chance of risk
the hazard ratio is 1.48 meaning the people on Metformin had a 48 greater chance of dying in any given year than their non-diabetic counterpart
When you adjust for age they're almost identical it's it goes from 29 point 24.93 to 24.7
and when you throw education in it goes up to an 80 chance of risk
in the twins it went from a hundred and fifteen percent down to only 97 percent
When you make that first adjustment of all the meds and marital status you bring it down to a 70 increase in risk
when you go to the twin group it's 24.73 to 12.94
if you do that all of a sudden the uh Hazard ratio drops from 1.48 to 1.32 which means yep you still have a 32 percent greater chance of dying in any given year
the unadjusted model is brutal 2.15 that's a hundred and fifteen percent think about this these are twins who in theory are the same in every way except one has diabetes and one doesn't and the one with diabetes on Metformin still has 115 percent greater chance of dying than the non-diabetic co-twin
when you adjust for age they're almost identical it's it goes from 29 point 24.93 to 24.7