The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Metformin is a drug given to type two diabetics to bring down their blood sugar levels. But it's been found that looking at tens of thousands of veterans and all those, that those two type two diabetics live longer than people that don't even get type two diabetes. So it's a longevity drug
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the people who took metformin and had diabetes had a 15 one five fifteen percent relative reduction in all-cause death over 2.8 years which was the median duration of follow-up
and in 2014 a paper came out by banister that basically got the world focused on this problem by the world I mean the world of of anti-aging so what what banister and colleagues did was they took a registry from the UK and they got a set of patients who were on Metformin with type 2 diabetes but only metformin so these were people who had just progressed to diabetes they were not put on any other drug just metformin and then they found from the same registry a group of matched controls so this is
the crude death rate in the group of people with type 2 diabetes who were on Metformin including the censoring was 14.4 so 14.4 deaths occurred per thousand patient years if you looked at the control group it was 15.2
the people who took metformin and had diabetes had a 15 one five fifteen percent relative reduction in all-cause death over 2.8 years which was the median duration of follow up
and in 2014 a paper came out by banister that basically got the world focused on this problem by the world I mean the world of of anti-aging so what what Bannister and colleagues did was they took a registry from the UK and they got a set of patients who were on Metformin with type 2 diabetes but only metformin
in 2014 uh banister at all published something that at the time was almost impossible to believe
because what's clear is that the diabetics taking metformin still had inferior glycemic control to the non-diabetics so in other words it's not that they are if they're living longer it's not because they have better glycemic control it would seem to be that it's they're better because of something else that metformin is doing outside of managing presumably hepatic glucose output