David Sinclair· PhD
Regarding aging, metformin, the diabetes drug, had mixed results in mice & mostly association data in humans.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Regarding aging, metformin, the diabetes drug, had mixed results in mice & mostly association data in humans.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
I also discuss metformin as a geroprotective agent, and more, including:
we do eventually start to talk about metformin which I know many people ask about and he provides a great insight into or several great insights into what metformin may or may not be doing
look you're right in humans you you can say it on many studies but it's certainly true with diabetes diabetes is a problem because it's a progressive disease no matter what and and you can go and go back to the data and show whether the people were metformin from the beginning versus other have done better and whether it stops and there's a lot of of of things but first of all you're right you're also right about we had this discussion about the mortality data and you pointed out that maybe the control were not controlled enough for getting them out for some reason you watch them all the time you're absolutely right even even the clinical studies are not perfect studies but there are still enough of clinical studies or small studies that gives you the confidence