Andrew Huberman· PhD
The mechanism by which metformin works is debated hotly but what I think is not debated is the immediate thing that metformin does which is it inhibits complex one of the mitochondria
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
The mechanism by which metformin works is debated hotly but what I think is not debated is the immediate thing that metformin does which is it inhibits complex one of the mitochondria
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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from our point of view we want to really nail down is it by inhibiting mitochondrial complex one
at the time was it understood what metformin x' activity was on complex one of the mitochondria now not really this came later
The mechanism by which metformin works is debated hotly but what I think is not debated is the immediate thing that metformin does which is it inhibits complex one of the mitochondria