I also discuss metformin as a geroprotective agent, and more, including:
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
I also discuss metformin as a geroprotective agent, and more, including:
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
I'm doing some cool self-experiments now with metformin and lactate production.
in particular I really loved the double double-click deep dive on metformin which is something I think a lot about myself hopefully once we have some results and there's more clinical trials I can come back and we can really talk about some more answers
actually going to volunteer for a study that will take some muscle biopsies and look at peak mitochondrial function which you can induce through certain types of exercise with and without metformin
I I'm still really yearning to understand the effect of Metformin in terms of pure mitochondrial function and performance in in a trained individual