David Sinclair· PhD
Metformin and calorie restriction both reduce IGF-1 levels, correlating with improved metabolic health and increased longevity in animal models.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Metformin and calorie restriction both reduce IGF-1 levels, correlating with improved metabolic health and increased longevity in animal models.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.