Metformin has been shown to extend lifespan and improve healthspan in worms and mice.

“Thought provoking study suggesting the diabetes & putative longevity drug metformin disrupts old mitochondria.”

“Well, first is my lab, in collaboration with Rafael de Cabo, down at the National Institute on Aging, showed in a mouse study that if you give them metformin, those mice are healthier and live longer.”

“In worms it's extended lifespans, 30 to 40 days, which is no small amount of extension for a worm. - Yeah I was involved in the mouse study with Rafael de Cabo down at the NIH and we found that the mice were healthier and longer lived on Metformin.”