Metformin and berberine can buffer blood glucose spikes, potentially mitigating negative effects of high-calorie or high-carbohydrate intake.

“metformin could buffer blood glucose and in some ways make me feel less sick when ingesting all these calories in in many cases um spiking my my blood sugar and Insulin um because you're having ice cream and you know Etc and indeed it worked so if I took berberine and I don't recall the milligram count and then I ate you know 12 donuts felt fine it was as if I had eaten one donut wow I felt sort of okay in my body and I felt much much better now um presumably because it's buffering the spikes in blood sugar I wasn't crashing in the afternoon nap and that whole thing”