Peter Attia· MD
And I'd say, you know, sometimes it's like 1.6, even before I start.
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And I'd say, you know, sometimes it's like 1.6, even before I start.
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Even with or without metformin, There's a coupling between heart rate. So for example, if you don't sleep well and your heart rate's higher, you're not recovered, your heart rate's higher, you're under more stress for some other reason and heart rate is higher, lactate tends to follow it even at the exact same power output.
i was realizing that i just had you know higher lactate levels than i wanted to and i thought about it and i was like wait this is obvious i'm taking a mitochondrial toxin of course my lactate levels are going to be higher
so then i did the experiment and i did all this sort of talking with a friend of mine inagosan milan who's also been on the podcast of stopping metformin and starting it again just to see if we could reproduce the effect and sure enough it was clearly the metformin that was allowing my lactate levels
in my experience both personally and with other patients uh metformin categorically lowers zone two so what we notice in patients on metformin is even fasting uh pardon me even at rest so before you do the test uh your their zone their their i'm sorry their their plasma lactate or you know capillary lactate can easily be close to two
no i mean it certainly is aligned to do that right and that's just backing up further it's just basically creating more of a roadblock into the tca is going to give you more lactate
it's as as sure as God made little green apples anybody on Metformin has higher lactate levels and that that's that's a bad thing or was a bad thing
I had always assumed that the the doubling at least doubling if not 3x increase in uh resting lactate levels in the case of Metformin were due to the mitochondrial the complex one inhibition right I mean that's you know just again obviously a maybe naive assumption but it was hey if you're inhibiting the electron transport chain of course you're going to have more lactate
Metformin which is a mitochondrial toxin right metformin impairs complex one of the mitochondria we immediately see a change in the lactate performance curve of an individual on Metformin we see a complete reduction in their Zone 2 output they hit that lacta of 2 much sooner we also see an increase not big but significant meaning clinically significant in their fasting resting lactate level