The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
I still remember exactly when I started I started it in May of 2011 and I realized that because I was on a trip with a bunch of buddies we went to the Berkshire Hathaway shareholder meeting which is uh you know the Buffett uh shareholder meeting and uh you know it was kind of like a fun thing to do and I remember being so sick the whole time because I didn't titrate up the dose of Metformin I just went straight to two grams a day which is kind of like the full dose
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
not quite as far back as the sort of metformin interest which started I think around 2010 2011 for me
so well i as i said i started metformin in 2010 the spring of 2010 may of 2010 i remember it very well actually and i stupidly just started at 2000 milligrams a day i didn't escalate the dose so i remember having lots of nausea for about two months and again some people if they just go straight to a high dose they do feel nauseous others usually when i put patients on it now we titrate them we go 500 at night then 500 bid a thousand at night 500 in the morning etc so that was my first beyond that i didn't even notice i was taking it so never a side effect again
joan i started taking metformin in 2010 that's when i sort of became pretty convinced about the data i started taking rapamycin in i want to say 2018 it's been about two years that was a bigger thing for me to jump but i stopped taking metformin around the same time
so I actually began taking metformin I still remember exactly when I started I started it in May of 2011 and I realized that because I was on a trip with a bunch of buddies we went to the Berkshire Hathaway shareholder meeting which is uh you know the Buffett uh shareholder meeting and uh you know it was kind of like a fun thing to do and I remember being so sick the whole time because I didn't titrate up the dose of Metformin I just went straight to two grams a day which is kind of like the full dose