The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
with with metformin uh if we give metformin and there's an increase in lactate uh in the plasma is that uh due to um production outstripping removal or is are we actually increasing the oxidation the oxidative disposal of um glucose or is the glucose H High because of increased glucogenesis we could answer all of these things with our combination of tracers
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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I want to give carbon 13 C lactate uh or carbon 13c glucose and look at the appearance of carbon 13c lactate in the blood and see and do the quantitation you described where does the glucose go how much would it cost to do the definitive experiments on the full flux disposal of lactate this doesn't strike me as staggeringly high amounts of money to do this type of research you could really we could start very well with an ro1 uh basic research Grant uh that's $2.5 million