There’s a lot of evidence in humans (not just in mice) that metformin likely protects against aging & diseases of aging — cancer, heart disease, Alzheimer’s & frailty.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
There’s a lot of evidence in humans (not just in mice) that metformin likely protects against aging & diseases of aging — cancer, heart disease, Alzheimer’s & frailty.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Retrospective studies of people taking metformin for diabetes indicate it might also protect those at high risk of cancer, cardiovascular disease, frailty and Alzheimer’s.
Studies of 10,000 people indicate it slows many aspects of aging - cancer, diabetes, heart disease, Alzheimer’s and even frailty.
But there's also metformin, which is a diabetes drug and that activates AMPK. And that's also by looking at tens of thousands of people, who take metformin for type two diabetes, been shown to slow down the occurrence, not just of diabetes, but other diseases of aging.
And one of the most interesting things about it is you can do a retrospective study of tens of thousands of elderly people on Metformin and ask, okay, their type two diabetes may be reduced and slowed down, but what about other diseases that they're susceptible to? Cancer, heart disease, Alzheimer's, frailty.
metformin is a really interesting compound i think we have excellent data than in diabetics it is a wonderful drug and there's some retrospective data of longevity in diabetics treated for a long time with metformin