We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
the reason I stopped and this will be the last thing before we move on well because you couldn't go to the Dairy Queen at the Buffett event no finally the nausea went away after a few weeks or a month maybe um but once I got really into lactate testing I noticed how high my lactate was uh at rest
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
I now would say I reserved metformin prescriptions for patients who obviously are in need of it from the standpoint of glucose and insulin regulation but I don't view it really as a pro longevity agent yet
my position today so I've stopped taking metformin after making this observation in December of 2018
the reason I stopped and this will be the last thing before we move on well because you couldn't go to the Dairy Queen at the Buffett event no finally the nausea went away after a few weeks or a month maybe um but once I got really into lactate testing I noticed how high my lactate was uh at rest so a resting fasted lactate should be in a healthy person should be below one like somewhere between 0.3.6 millimole and only when you start to exercise should lactate go up and in 2018 was when I started blood testing for my zone two