Metformin acts as a weak inhibitor of mitochondrial respiration at complex I, leading to reduced ROS production and inflammation.

“it's a mitochondrial toxin throw we published a paper that it increases Ross production from the complex one of the mitochondria so it's inhibiting complex one it's inhibiting yeah mildly inhibiting complex one and it's triggering what the cell experiences as an energetic crisis and then you know it has an activation of amp kinase 2”

“but metformin is the weak cyanide hmm okay look what cyanide acted at complex for right but right oh you just mean more broadly speaking right it inhibits oh yeah there is less ro s production okay and then there is less inflammation and there is other things that's going just because the mitochondria is less oxidative pathway going down”

“metformin is a weak mitochondrial toxin it inhibits complex one that tricks the body basically into doing something which is thinking nutrients are scarce amp kinase goes up it thinks there's a deficiency of energy”

“well we know it has a Target in the mitochondria complex one it inhibits we knows besides that's my point it's not in the muscle that's a question and and we also know that it activates amk yep uh interestingly a friend of all of our those mechanisms probably related yes yes yes”