Rhonda Patrick· PhD
However, it may also inhibit exercised-benefits such as cardiorespiratory and lean body mass gains.
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
However, it may also inhibit exercised-benefits such as cardiorespiratory and lean body mass gains.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Metformin inhibits mitochondrial adaptations and improvements in cardiorespiratory fitness after aerobic exercise training in older adults.
Combining metformin with high-intensity exercise interferes with improvements in VO₂ max and vascular insulin sensitivity.
But then there's been a couple of randomized controlled trials that have come out since then showing that healthy...so people that don't have type 2 diabetes. Healthy people that are physically active, doing resistance training, and/or even aerobic exercise, when they take metformin, it blunts some of the benefits, exercise-induced benefits that are improving a variety of things.