Combining metformin with high-intensity exercise interferes with improvements in VO₂ max a

Partially SupportedMetformin inhibits mitochondrial complex I, interfering with exercise adaptations and cellular energy sensing.

Well SupportedMetformin is a very safe drug, available affordably in many parts of the world, and is a frontline therapy for Type 2 diabetes.

Not SupportedMetformin inhibits mitochondrial adaptations and improvements in cardiorespiratory fitness after aerobic exercise training in older adults.

Partially SupportedMetformin blunts increases in macrovascular and microvascular insulin sensitivity seen with exercise.

Not Supported