David Sinclair· PhD
What some people are doing just in an abundance of caution is taking Metformin on days that they don't exercise.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
What some people are doing just in an abundance of caution is taking Metformin on days that they don't exercise.
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it would be another thing if you're more in the Ross category that you alluded to earlier is this actually undoing some of the benefit
look i'm i'm taking that for me an exercise but i have a different way i'm thinking about it for me right now we're very personalized and and and this is back to the issue of when do we we start metformin and or what is the biological age of those people who exercise and take metformin and i would say that if you're young or biologically young i don't think you should take metformin when you exercise at this level
it's a mitochondrial inhibitor uh it's a weak one at the doses we take it but it nevertheless is so it seems to me that that's the most obvious explanation that's the place i'd be looking for the fire given where the smoke is
people have looked a little bit a little bit although again I would say even there the data is not definitive yet but you're right there have been some studies where people have looked at the effects of metformin on exercise both resistance training and uh cardiovascular training yeah and I I'd say the data is unclear although there is some reason to think that metformin might impair the what people think of as the positive responses to exercise
metformin but confused by the recent studies showing it blunts some of the positive effects of different types of exercise?
This is not isolated; other trials show metformin interferes with multiple exercise adaptations, likely via inhibition of mitochondrial complex I, which disrupts cellular energy sensing.
Reminds me of metformin (also once marketed as a "longevity drug"), which also blunts exercise adaptations in certain contexts.