David Sinclair· PhD
Improves memory:
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Improves memory:
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
The one that I want to bring up is Koenig and colleagues in 2017, a really good study. It's randomized, placebo-controlled crossover. That's what you always look for. Metformin improved, again, this executive functioning, the ability to focus, by treating 20 non-diabetic normal subjects. And they had mild dementia when they started, and they improved, which means that dementia is somewhat reversible with this drug.
There's also a really big, less well controlled study, but nonetheless really impressive study from 2019. It took a really huge cohort of diabetic patients, tens of thousands of them. Dementia incidence for the metformin users, 55% lower.